Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers
Identifieur interne : 002089 ( Main/Exploration ); précédent : 002088; suivant : 002090Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers
Auteurs : Mary Lou Clements ; Mark H. Snyder ; Stephen D. Sears ; Hunein F. Maassab ; Brian R. MurphySource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1990.
Abstract
A cold-adapted (ca) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from ca influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The ca reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 106,4 TCID50. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of ca virus (107,5 TCID50) were challenged experimentally with homologous wild-type influenza B virus. The ca vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the ca influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. Such reassortants may be suitable vaccines for healthy adults.
Url:
DOI: 10.1093/infdis/161.5.869
Affiliations:
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Murphy</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-05">1990</date><biblScope unit="vol">161</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="869">869</biblScope><biblScope unit="page" to="877">877</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">A cold-adapted (ca) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from ca influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The ca reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 106,4 TCID50. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of ca virus (107,5 TCID50) were challenged experimentally with homologous wild-type influenza B virus. The ca vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the ca influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. 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